Science & Tech

Traditional CRISPR–Cas9 transformed genetics by giving scientists a programmable way to cut DNA at selected locations. Once the DNA is cut, the cell’s repair machinery can disrupt a gene or, under certain conditions, incorporate a corrected sequence. This approach has produced the first approved CRISPR therapy, but a double-strand DNA break is not always the

Gene editing has entered clinical medicine, but the first approved CRISPR treatment does not edit genes directly inside the patient. Instead, cells are removed, modified in a laboratory, and returned to the body. This approach is known as ex-vivo editing and provides scientists with significant control over the process. However, it also requires individualized manufacturing,

For years, CRISPR was discussed as a technology that might eventually transform medicine. That future has now begun. The first CRISPR-based treatment, Casgevy, was authorized in the United Kingdom in 2023 and approved by the U.S. Food and Drug Administration shortly afterward. It is used for sickle cell disease and transfusion-dependent beta-thalassemia, two inherited blood

Dr. Christina Rahm has an extraordinary mind with a passion for helping others. Her Native American and Eastern European heritage influenced her approach to health and wellness. She has a multifaceted education from Cornell and Harvard Universities in nanotechnology, pharmaceutical management, nutrition, education, and philosophy, as well as a Master of Science. Share this article