Abstracts

Qixiao Zhai, Arjan Narbad, and Wei Chen Cadmium (Cd) and lead (Pb) are toxic heavy metals that cause adverse health effects in humans and animals. Chelation therapy, the conventional treatment for heavy metal toxicity, is reported to have a number of safety and efficacy issues. Recent studies have shown that dietary supplements play important roles…...

Wassana Yantasee, Ryan D. Rutledge, Wilaiwan Chouyyok, Vichaya Sukwarotwat, Galya Orr, Cynthia L. Warner, Marvin G. Warner, Glen E. Fryxell, Robert J. Wiacek, Charles Timchalk, and R. Shane Addleman In this study, researchers developed a thiol-modified nano-porous silica material (SH-SAMMS) as an oral therapy for the prevention and treatment of heavy metal poisoning. •The results…...

Lead, one of the most toxic heavy metals, takes a longer time to be excreted from the body than other heavy metals. In this study, Lead, one of the most toxic heavy metals, takes longer time to be excreted from the body than other heavy metals. The purpose of this study is, by measuring lead…...

Hui Duan, Leilei Yu, Fengwei Tian, Qixiao Zhai, Liuping Fan, and Wei Chen The gut microbiota is the first line of defense against the toxic effects of heavy metals. Heavy metal exposure alters the composition and metabolic profile of the gut microbiota at the functional level. Moreover, the gut microbiota can affect the integrity of…...

Arif Hussain, Chhavi Sharma, Saniyah Khan, Kruti Shah, and Shafiul Haque ABSTRACT Many of the anti-cancer agents currently used have an origin in natural sources including plants. Aloe vera is one such plant being studied extensively for its diverse health benefits, including cancer prevention. In this study, the cytotoxic potential of Aloe vera crude extract (ACE) alone or in…...

Susumu Okabe, Toshihiro Okamoto, Chun-Mei Zhao, Duan Chen, and Hirofumi Matsui ABSTRACT We recently reported that topical application of acetic acid promptly caused tumor necrosis in a mouse model of gastric cancer. The aim of the present study was to examine whether acetic acid can directly induce cancer cell death. Acetic acid promptly induced the cell death of RGM-1,…...

Jeong-Hyeon Ko,Gautam Sethi, Jae-Young Um,Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar,Anupam Bishayee, and Kwang Seok Ahn ABSTRACT Compounds that modulate oncogenic processes can be considered as potential anti-cancer agents that may ultimately make it to clinical application. Resveratrol, a natural stilbene and a non-flavonoid polyphenol, is a phytoestrogen that possesses anti-oxidant, anti-inflammatory, cardioprotective, and…...

Yuichi Nakajima  , Radha Madhyastha, Masugi Maruyama ABSTRACT Thymidine phosphorylase (TP, EC 2. 4. 2. 4), an enzyme involved in the reversible conversion of thymidine to thymine, is an important mediator of angiogenesis, tumorigenicity, metastasis and invasion. The angiogenic effect of TP requires the enzymatic activity of TP. TP activity is expressed at higher levels in a…...

Multiple sources of evidence support a role for diminished dopaminergic neurotransmission in depression. Moreover, negative symptoms, as well as extrapyramidal symptoms and certain depressive symptoms, may be manifestations of regionally deficient dopaminergic activity. https://jamanetwork.com/journals/jamapsychiatry/article-abstract/482227… This content is for Associate, Professional , Associate (Annual) , and Professional (Annual) members only.Login Join Now...