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Abstracts

Abstracts

What is Vitamin D3 (Cholescalciferol)?

Julie Marks and  Sanjai Sinha, MD To help the body absorb calcium, vitamin D3, also known as cholecalciferol, is important for the body. This supplement is typically used for people who have vitamin D deficiency or similar disorders. The people in those categories include older adults, breastfed babies, people with darker skin, obese individuals, and…...

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Vitamin D3

Vitamin D is a vital vitamin that helps the body absorb calcium and phosphorus. All three together is very important for strengthening the bone. This vitamin is used for the treatment of bone disorders or to treat or prevent bone loss (osteoporosis). Furthermore, vitamin D combined with other medications may be able to treat low…...

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The Role of Glutathione in Viral Diseases of the Central Nervous System

Juliana Echevarria Lima Many infectious pathogens, including bacteria, fungi, parasites, and viruses, are causative agents of central nervous system illnesses. Infections are a leading source of illness and mortality across the world. The development of meningitis and encephalitis is mostly linked to viral CNS diseases. However, viral infections are linked to CNS illnesses defined by…...

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Antiviral and Immunomodulatory Properties of New Pro-Glutathione Molecules

A Fraternale, M F Paoletti, A Casabianca, J Oiry, P Clayette, J-U Vogel, J Cinatl Jr, A T Palamara, R Sgarbanti, E Garaci, E Millo, U Benatti, and M Magnani In mammalian cells, reduced glutathione (GSH) is found in millimolar concentrations. It is involved in a variety of cellular functions, including detoxification, amino acid transfer, coenzyme synthesis, and vitamin E and C recycling. To maintain the decreased…...

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GSH and Analogs in Antiviral Therapy

Alessandra Fraternale, Maria Filomena Paoletti, Anna Casabianca, Lucia Nencioni, Enrico Garaci, Anna Teresa Palamara, and Mauro Ma In animal cells, reduced glutathione (GSH) is the most common non-protein thiol. Its de novo and salvage synthesis helps to keep the cellular environment under control. GSH is the most effective intracellular antioxidant, and glutathione-S-transferases (GST) and glutathione peroxidases catalyze the detoxification of a…...

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Glutathione Against Cancer and Viral Infections

Dr. Mark Sircus COVID patients in ICU with serious lung impairment benefit from nebulized bicarbonate. As a result, this formula will be beneficial for all lung diseases, such as lung cancer, pneumonia, asthma, emphysema, idiopathic pulmonary fibrosis, cystic fibrosis, and lung disease in HIV patients. Glutathione, the body’s most important antioxidant, is where sulfur and…...

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Glutathione Fine-Tunes the Innate Immune Response Toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

Marina Diotallevi, Paola Checconi, Anna Teresa Palamara, Ignacio Celestino, Lucia Coppo, Arne Holmgren, Kahina Abbas, Fabienne Peyrot, Manuela Mengozzi, and Pietro Ghezzi Glutathione (GSH), a significant cellular antioxidant, is thought to suppress the inflammatory reaction caused by reactive oxygen species (ROS) (ROS). Experiments with exogenously applied antioxidants/reducing agents or pro-oxidants, on the other hand, account…...

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Glutathione Fine-Tunes the Innate Immune Response Toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties Read More »

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

Alexey Polonikov The majority of older people and those with comorbidities have higher rates of severe illness and death from coronavirus SARS-CoV-2 infection suggests that age, and disease-related biological mechanisms make these people more vulnerable to environmental stress factors, like infectious agents including coronavirus SARS-CoV-2. The aim of this Viewpoint is to demonstrate (1) the…...

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The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

Liqiang Wang, Rui Yang, Bochuan Yuan, Ying Liu, and Chunsheng Liu For centuries, licorice is an herb that has been used in traditional Chinese medicine, and recent studies have reported that the 20 triterpenoids and newly 300 flavonoids possess many pharmacological activities, including antiviral, antimicrobial, anti-inflammatory, anti-tumor, and more. Among these activities, antiviral and antimicrobial…...

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